DEVELOPMENT OF MAGNESIUM-BINDING COMPOUNDS BASED ON NATURAL SAPONINS: PHYSICOCHEMICAL CHARACTERIZATION AND STABILITY ANALYSIS

Abstract

Magnesium plays a crucial role in numerous biochemical and physiological processes, yet its low bioavailability and instability in conventional formulations limit its therapeutic and nutritional applications. Natural saponins, known for their amphiphilic structure and metal-binding potential, represent a promising platform for the development of magnesium-binding compounds. The present study focuses on the synthesis of magnesiumcontaining complexes based on plant-derived saponins and their comprehensive physicochemical characterization. Magnesium–saponin compounds were obtained using controlled complexation methods and analyzed in terms of structural features, binding efficiency, solubility, and stability under varying pH and temperature conditions. Spectroscopic and analytical approaches were employed to elucidate the interaction mechanisms between magnesium ions and saponin functional groups. The results demonstrate that natural saponins effectively stabilize magnesium ions through coordination interactions, leading to improved physicochemical stability compared to conventional magnesium salts. These findings highlight the potential of saponin-based magnesium compounds as advanced biomaterials for pharmaceutical, nutraceutical, and biomedical applications