DISTINCTIVE CLINICAL COURSE ANDPROPHYLAXIS OF POLYPOIDRHINOSINUSITIS

Abstract

Chronic polypoid rhinosinusitis (CPR) represents a complex form of chronic rhinosinusitis characterized by mucosal inflammation, nasal polyp formation, and significant morbidity. Despite advances in endoscopic sinus surgery and topical pharmacotherapy, CPR remains prone to relapse and complications. This review synthesizes current knowledge on the unique clinical features, immunopathology, and evidence-based prevention strategies for CPR. We examine the interplay of environmental, microbial, and host factors that drive polypogenesis, outline the stages of disease progression, and critically assess prophylactic measures— including pharmacologic maintenance, immunotherapy, and lifestyle modifications. Recommendations for personalized prevention algorithms are proposed, aiming to reduce recurrence rates and improve patient quality of life.